A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis

Rhomboid family members are widely conserved and found in all three kingdoms of life. They are serine proteases and serve important regulatory functions. In the present study, a novel gene highly expressed in the testis, RHBDD1, is shown to be a new member of the Rhomboid family, participating in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. The RHBDD1-involved proteolytic modification is upstream of the BIK protein degradation pathway. Mutagenesis studies show that the amino acid residues glycine142 and serine144 of RHBDD1 are crucial for its activity in cleaving BIK at a site located in the transmembrane region. Overexpression or knock-down of RHBDD1 in HEK 293T cells can reduce or enhance BIK-mediated apoptosis, respectively. The present findings suggest that, by acting as a serine protease, RHBDD1 modulates BIK-mediated apoptotic activity. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. Received 31 July 2008; received after revision 16 September 2008; accepted 19 September 2008     

Comparison of dark energy models: A perspective from the latest observational data

Physicists at the Institute of Theoretical Physics, Chinese Academy of Sciences and the Department of Physics at Northeastern University have made a comparison of a number of competing dark energy models. They have tested and compared nine popular dark energy models using the latest observational data. The study was reported in Issue 9 (Volume 53) of SCIENCE CHINA Physics, Mechanics & Astronomy because of its significant research value.
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不同砧木对西瓜嫁接效果的影响

以日本南瓜、瓠子、黑籽南瓜为砧木,嫁接郑杂九号西瓜进行试验。结果表明,日本南瓜和瓠子与郑杂九号的亲和性较好,黑籽南瓜稍差。三种砧木都能较明显地提高嫁接苗的抗病性和商品瓜产量,对品质影响不大。三种砧木的嫁接效果为黑籽南瓜稍差。     

中国健康中年男性血沉参考值与地理关系

收集了中国各地用温氏法测定的健康中年男性血沉参考值，并对其与地理因素的关系进行了研究，发现海拔高度是影响健康中年男性血沉参考值最主要的因素，随着海拔高度的逐渐增大，中年男性血沉参考值（温氏法）在逐渐减小，相关性很显著，用逐步回归分析的方法推导出了一个回归方程，如果知道了中国某地的地理因素，就可以用回归方程估算这个地区的健康中年男性血沉参考值（温氏法），依据健康中年男性血沉参考值（温氏法）与地理因素的依赖关系分为青藏区、西南区、西北区、东南区、华北区、东北区等６个区。     

药剂学理论与实验教学的改革

目的:探索药剂学教学模式以满足培养应用型人才的需要.方法:根据我校高素质应用型人才培养目标要求,结合药学专业实情,对药剂学的理论教学、实验教学与考核方法三个方面进行改革.结果:教学模式的改革调动了学生学习的积极性,使其充分发挥学习的主体作用,增强了学生的实践和应用能力.结论:以能力培养为主的教学模式为培养高素质应用型人才提供了保障.     

个体攻击性及其模式的理论探讨

通过对国内外攻击行为理论的相关研究,探讨了个体攻击性的定义和其内在模式,旨在减少攻击行为的发生。     

一种新颖的“北斗”卫星导航定位系统的数据处理方法

由于"北斗"定位卫星数量的限制,接收机在动态定位的精度上会出现较大的误差.针对这一问题,提出采用描述载体运动的"当前"统计模型,建立北斗无源动态定位卡尔曼滤波模型.针对可能导致滤波发散的"野值",提出将χ2:检验法与新息加权法相结合的处理方法.通过跑车实验,验证了建立的模型能很好的改善定位的精度及动态性能.     

关于可展曲面的两点注记

探讨了满足条件(a′(u),b(u),b′(u))=0的直纹面r(u,v)=a(u)+vb(u)为可展曲面的合理性,验证了只有一族直母线是可展曲面的必要但不充分条件.然后给出可展曲面的又一等价条件.     

《四元玉鉴》的清代版本及《假令四草》的校勘研究

该文通过对《四元玉鉴》不同版本的对校及对清代有关该书的多种史料的研究，较为全面地阐述了《四元玉鉴》在清朝的流传及版本情况，指出罗士琳《四元玉鉴细草》本中《假令四草》的术，草均已经校改，并对其校改者进行初步推断。     

基于面向对象分析和设计的神经网络建模系统

针对目前神经网络建模工具的不足，进行了网络的面向对象分析。并采用面向对象的编程技术，实现了通用性强的可视化建模工具，解决了多层网络的建模难题。